Description
Introduction: Zinc Finger, AN1-Type Domain 5, also known as ZFAND5 is implicated in protein degradation through the ubiquitin-proteasome system. ZFAND5 performs by anchoring ubiquitinated proteins to the proteasome and takes part in ubiquitin-mediated protein degradation during muscle atrophy. Furthemore, ZFAND5 plays a role in the regulation of NF-kappa-B activation as well as apoptosis. ZFAND5 inhibits NF-kappa-B activation as well as tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation.
Description: ZFAND5 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (1-213 a.a) and having a molecular mass of 25.5kDa (Molecular size on SDS-PAGE will appear higher). ZFAND5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques